Loading…
Please register to continue your trial period!
meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Aberrant glycosylation is a common feature in human cancers, with changes in mucin-type O-glycosylation playing a crucial role. These alterations contribute significantly to cancer invasion and metastasis by creating new cancer-specific glyco-antigens. These antigens interact with immune cells through carbohydrate-binding lectins. MUCIN-1 (MUC1) carrying both Tn (GalNAc-O-Ser/Thr) and Sialyl-Tn (STn) / Neu5Acα2-6GalNAc-O-Ser/Thr can bind to the C-type lectin MGL. The tumor-associated STn is linked to poor prognosis and chemotherapy resistance in [breast carcinomas](brain://2ihGumTA6E2cOgZUJGFZ6w/BreastCance…