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Janus family kinases inhibitors (JAKis) have the potential to finely tune immunity and inflammation in patients with rheumatoid arthritis. In vitro data indicates that IL-6 signaling is suppressed by all JAK inhibitors. Currently, there are five Janus family kinases inhibitors (JAKis) approved for treating rheumatoid arthritis. These inhibitors vary in their selectivity for different JAK isoforms. Despite their specific target profiles, any of these drugs can inhibit other Janus Family Kinases (JAKs) if their bloo…