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In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has led to durable complete and partial responses in a large number of patients.
Additional checkpoint therapies, such as relatlimab, an [Anti-Lymphocyte-activation gene 3 (LAG-3) antibodies](brain:/…