Circadian Clock / Circadian rhythm & Dysbiosis

From mice experiments, it can be concluded:

• Weekly phase reversals of the light:dark (LD) cycle did not alter the microbiome in mice fed standard chow.


• Mice fed a high-fat, high-sugar diet in conjunction with phase shifts in the light:dark cycle exhibited significantly altered microbiota.

While it is yet to be established if some of the adverse effects associated with circadian disorganization in humans (e.g., shift workers, travelers moving across time zones, and individuals with social jet lag) are mediated by dysbiosis, the current study demonstrates that circadian disorganization can impact the gut microbiota. This finding may have implications for inflammatory diseases.
Voigt et al. 2014 PLoS ONE 9: e97500. doi: 10.1371/journal.pone.0097500

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