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In mice, Butyrate suppresses cytokine (Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g), Interleukin-4 (IL-4), Interleukin-2 (IL-2), and Interleukin-13 (IL-13)) production by Type I Natural Killer T cell due to inhibition of class I histone deacetylases. Also, butyrate production by gut microbiota reduces Ab-induced arthritis (AIA) by inhibiting cytokine …