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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

Protein kinases C (PKCs) & Tight-Junction Molecules / Tight Junction Proteins

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Leucine-Rich Repeat-Containing Protein 19 (LRRC19) degrades Protein kinase C (PKC) zeta / PRKCZ and PKCι/λ. This reduces Zonula Occludens Protein-1 (ZO-1), Zonula Occludens Protein-3 (ZO-3), and Occludin and the intestinal barrier becomes more permeable.
Su et al. 2021 Inflamm Bowel Dis. 27: 1302

Tight-Junction Molecules / Tight Junction Proteins may be selectively regulated by PKCs …

References (Sources)

Cell polarity: the ups and downs of the Par6/aPKC complex
Henrique & Schweisguth 2003 Curr Opin Genet Dev. 13: 341-350
LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin
Su et al. 2021 Inflamm Bowel Dis. 27: 1302
PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels
Lu et al. 2015a Mol Biol Cell. 26: 1523-1531.
Prostaglandins protect human intestinal cells against ethanol injury by stabilizing microtubules—role of protein kinase C and enhanced calcium efflux
Banan et al. 1999 Digest Dis Sci 44: 697-707
Protein kinase C regulates the phosphorylation and cellular localization of occludin
Andreeva et al. 2001 J Biol Chem. 276: 38480-38486
Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions
Jain et al. 2011 Biochem J. 437: 289-299
Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation
Helfrich et al. 2007 J Invest Dermatol. 127: 782-791

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