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Intrapyloric injection of botulinum toxin, delivered at endoscopy, has been investigated as a management strategy in Diabetic Gastroparesis, albeit with unconvincing results.
It is postulated that the Neurotoxins inhibits the release of acetylcholine at the neuromuscular junction, causing pyloric paralysis and allowing gastric contents to empty more readily into the duodenum.
Ukleja et al. 2015 World J Gastrointest Endosc. 7(8):790–8
[Botulinum toxin](bra…