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Biofilm growth and drug efflux are significant obstacles in the treatment of bacterial infections. Recent research has uncovered the mechanisms behind efflux and biofilm-related antimicrobial tolerance, revealing a connection between the two.
New findings indicate that efflux impacts cell physiology and contributes to antibiotic tolerance. Additionally, efflux plays a role in cell interactions within biofilms. This interaction occurs through signaling molecules, pump components, and local antibiotic gradients.
The prevalence of death from infection in unvaccinated humans is generally driven by age.
Abel & Casanova 2024 Immunity 57(7…