Infection Diseases / Infections / Bacterial Infection

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What pathways mediate a bacterial infection?

Bacterial infection occurs through Toll-like receptor Signal transduction / Signal transduction pathway and Immune deficiency (IMD) signal transduction / signal transduction pathway (1)

What is the relationship between drug efflux, bacterial biofilms, and antibiotic tolerance?

Biofilm growth and drug efflux are significant obstacles in the treatment of bacterial infections. Recent research has uncovered the mechanisms behind efflux and biofilm-related antimicrobial tolerance, revealing a connection b…

References (Sources)

A Case for Phosphoinositide 3-Kinase–(PI3K) Targeted Therapy for Infectious Disease
Adefemi et al. 2020 J. Immunol 205: 3237
Review
Antimicrobial efflux and biofilms: an interplay leading to emergent resistance evolution
Vareschi et al. 2025 Trends in Microbiology 33(9): 1018
Review
From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
Casanova & Abel 2022 Cell 185: 3086-3103
Review
Infectious and lifestyle modiﬁers of immunity and host resilience
Bajpai & Nahrendorf 2021 Immunity 54: 1110-1122
Review
PD-1 Expression during Acute Infection Is Repressed through an LSD1–Blimp-1 Axis
Bally et al. 2020 J. Immunol 204: 449
Peptidoglycan recognition proteins: modulators of the microbiome and inflammation
Royet et al. 2011
Review

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