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The members of the interferon lambda protein family (Interferon type III (IFN Type III)) signal through the receptor complex IFNLR1 / Interleukin 28 receptor alfa subunit and Interleukin-10 receptor beta (IL10RB). As a result, they share antiviral roles with the Interferons Type I (IFN Type I), but show tissue-specific activity, particularly at epithelial barriers.
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