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In the context of Interleukin-22 (IL-22) & Self antigens / Autoantigens / Autoimmunity, Type 3 innate lymphoid cells (ILC3) and CD4+ T cells are the primary producers of Interleukin-22 (IL-22) (1). It is involved in preserving an intact epithelium, maintaining a balanced microbiota, and a functioning defense system against external threats. Uncontrolled IL-22 production can lead to the progression of autoimmunity and cancer (2).
(1)
(2) Sabihi et al. 202…