Cholera Toxin Vaccination

Cholera toxin (CT) plays a crucial role in the development of cholera vaccines and has been extensively studied for its potential as a vaccine component and adjuvant.

Cholera toxin is composed of two subunits: the A subunit (CTA) and the B subunit (CTB). The B subunit, in particular, has shown promise in vaccine development:

• The whole-cell/recombinant B subunit (WC/rBS) oral cholera vaccine, such as Dukoral, incorporates CTB as a key component

Shi et al. 2010 Zhonghua Yi Xue Za Zhi 90(3): 192-5
Dash et al. 2024 mSphere 9(3): e0056523

Vaccination with CTB-containing vaccines elicits significant antibody responses in both adults and children. In a study of Olympic volunteers and workers, the oral WC/rBS cholera…