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Vonoprazan may increase the risk of intestinal infection more than Proton Pump Inhibitors (PPIs). In particular, Vonoprazan may promote Clostridium difficile (C. difficile) infection by reducing the genera that prevent C. difficile infection, such as Blautia and [Coprococcus]
Vonoprazan may also dose-dependently increase serum gastrin levels, which are suspected of causing gastric carcinoids in an animal model
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