Type VII Secretion Systems (T7SS)

Type VII Secretion Systems (T7SS) were initially described in Mycobacterium. Although these organisms are considered gram-positive, they possess a unique cell envelope. This envelope consists of a plasma membrane and an outer mycomembrane that features mycolic acids.
Willey et al. 2023 McGraw Hill, USA, ISBN 978-1-265-12303-1

Secretion of proteins across both membranes requires a specialized secretion system, similar to those found in gram-negative bacteria. Mycobacterium tuberculosis utilizes Type VII Se…