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Metformin has been studied for its anticancer effects by regulating T cell functions.
The frequencies of memory stem and central memory T cells increased for both in peripheral and tumor-infiltrating CD8 + T cells in metformin-treated lung cancer patients compared with those not taking the medication
AMP-activated protein kinase (AMPK) activation decreased microRNA-107 expression, thus enhancing Eomesodermin expression, which suppressed the transcription of PDCD1 in metformin-treated CD8 + T cells. In the CAR-T cell therapy model, metformin also exhibited cytotoxicity-promoting effects that led to decreased tumor growth. Metformin could reprogram the differentiation of CD8 + T cells, which may benefit the clinica…