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The term "ODN TTAGGG" refers to a synthetic oligonucleotide (ODN) containing 4 repeats of the immunosuppressive TTAGGG motif commonly found in mammalian telomeric DNA.
This specific ODN, also known as A151, has been identified as a TLR9 antagonist that inhibits immune activation by CpG-containing ODNs.
Additionally, it has been found to be a suppressor of multiple pattern recognition receptors (PRR), including TLR9, AIM2, and Cyclic GMP-AMP synthase (cGAS), making it useful for immunomodulatory studies
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