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In rats, the effect of VSL#3 TM was studied in an irinotecan-induced diarrhea model.
When administered before and after chemotherapy, VSL#3 reduced weight loss after irinotecan. In these rats, moderate and severe diarrhea was also prevented. This was associated with a significant increase in crypt proliferation combined with inhibition of apoptosis in both the small and large intestines. VSL#3 also prevented irinotecan-induced increases in goblet cells in jejunal crypts.
It is still uncertain whether VSL#…