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Thus, antibodies directed against CD279 (Programmed cell death protein 1 (PD-1) or CD274 (Programmed death-ligand 1 (PD-L1)) block the inhibitory immune checkpoint interaction between CD8+ T cells and tumor cells, rehabilitating cytotoxic T cells to efficiently eliminate target cancer cells
CD279 (Programmed cell death protein 1 (PD-1) is expressed principally by T cells and other immune cells (including NK cells, DCs, and B cells), whereas its ligand, [CD274 (Programmed death-ligand 1 (PD-L1))](brain://1ZGF8qhXEUKcaS…