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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Antimicrobial Peptides (AMPs) & Interleukin-18 (IL-18)

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Induction of Antimicrobial peptides (AMPs) by Interleukin-18 (IL-18) was dependent on NFKB signaling
Levy et al. 2015 CELL 163: 1428-1443

AMPs induced by IL-18 were ITLN1 / Intelectin-1, RELM-beta, and members of the Angiogenin Family family, for which a microbicidal activity has been previously reported
Tsuji et al. 2001 The Journal of biological chemistry. 276:…

References (Sources)

Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall.
Tsuji et al. 2001 The Journal of biological chemistry. 276: 23456-23463
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
Levy et al. 2015 CELL 163: 1428-1443
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
Artis et al. 2004 Proceedings of the National Academy of Sciences of the United States of America 101: 13596-13600

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Antimicrobial Peptides (AMPs) & Interleukin-18 (IL-18)

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