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Hirschsprung’s Disease (HSCR) is the best known hereditary enteric neuropathy affecting 1 in 5000 individuals. The absence of ganglia in distal portions of the gut results in brutal expulsion of meconium, causing life-threatening intestinal occlusion and, over time, intractable constipation due to the lack of peristalsis in this intestinal region.
An Enteric nervous system (ENS) pathogenesis is considered to be the cause of Hirschsprung’s Disease (HSCR).
In Hirschsprung's disease, nerve cells of the ENS are missing in a section of the large intestine, which causes the muscles there to contract and the…