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Median OS values in both arms were the longest reported in phase III studies of Rd-based triplets in relapsed or refractory multiple myeloma at the time of this analysis; progression-free survival benefit with ixazomib-Rd versus placebo-Rd did not translate into a statistically significant OS benefit on intent-to-treat analysis. OS benefit was greater in subgroups with adverse prognostic factors. OS interpretation was confounded by imbalances in subsequent therapies received, especially PIs and daratumumab
Ixazomib is the first orally available proteasome inhibitor FDA approved in combination with lenalidomide and [dexamethasone](brain://G69qL-1NeFq8N2tMiPeXAg/Dexametha…