Most butyrate is cleared by the liver to avoid blood accumulation and toxicity, resulting in only trace amounts reaching the systemic circulation
Butyrate inhibits Bacteroides
Butyrate inhibition depends on which sugar a given Bacteroides strain uses.
Butyrate is an essential fuel for the colonocytes , and impairment in fuel supply may play a role in reduced gastrointestinal functioning
Resistant starch from potatoes (RPS) resulted in the most significant increase in total SCFAs, including butyrate
Acetate is converted into butyrate by defined subsets of colonic bacteria
Among bacterial metabolites, butyrate is biologically most relevant
see also:
Butyrate-producing bacteria
Microbial SCFA Production