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G-Protein Coupled Receptor 109a (GPR109a) (encoded by niacr1 gene) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by the gut microbiota and suppresses intestinal inflammation.
G-Protein Coupled Receptor 109a (GPR109a) signaling promotes anti-inflammatory properties in colon macrophages and dendritic cells and enables them to induce the differentiation of Treg cells and IL-10-producing T cells.
Furthermore, G-Protein Coupled Receptor 109a (GPR109a) was essential …