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Metastatic leiomyosarcomas have a poor prognosis, and currently doxorubicin alone is used as the standard first-line treatment.
Pautier et al. 2022 Lancet Oncology 23: 1044-1054
Anthracyclines are the basis of first-line chemotherapy for STS
Multi-agent chemotherapy has not been shown to improve overall survival compared with doxorubicin alone, although some studies have documented a higher response rate and longer progression-free survival (PFS) with combination therapy
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