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Clostridium symbiosum as a key bacterial player in colorectal tumorigenesis, enriched in tumor tissues of colorectal cancer (CRC) patients and linked to higher adenoma recurrence. In murine models, C. symbiosum promotes colonic stem cell proliferation and cancer stemness by enhancing cholesterol synthesis through branched-chain amino acids (BCAAs), activating [Sonic hedgehog signaling](brain://e3KqYfqDjEO9RJZ9AWUc4g/SonicHedgehogSignali…