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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)

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CD4+ CD25+ Treg

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What are the markers of activated CD4+ CD25+ Treg?

CD4+, CD25 high, FoxP3 high, CD45RA-, CD45RO+, CD127 low HLA-DR -, CD95+, CTLA4+, Ki67+, ICOS+/- . They are thought to be derived from the same lineage as naïve CD4+ cells
Curiel 2007 The Journal of Clinical Investigation 117(5): 1167

What is generally the role of activated CD4+ CD25+ Treg?

CD4+ Foxp3+ T Regulatory (Treg) cells are crucial for immune system balance and maintenance. They suppress T cell responses
Buszko & Shevach 2020 Current Opinion in Immunology 67: 18-26

Natural CD4+ CD25+ Treg constitute <5% of peripheral CD4+ T cells in hum…

References (Sources)

Control of regulatory T cell homeostasis
Buszko & Shevach 2020 Current Opinion in Immunology 67: 18-26
Review
Differentiation of T Regulatory Cells by Immature Dendritic Cells
Roncarolo et al., 2001
Ex vivo isolation and characterization of Cd4+Cd25+ T cells with regulatory properties from human blood
Dieckmann et al. 2001 J Exp Med 193: 1303-1310
Expression of Helios in peripherally induced Foxp3+ regulatory T cells
Gottschalk et al. 2012 J Immunol 188(3): 976-980
Foxp3 + T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study
Shevach 2018 Front Immunol 9: 1048
Review
Naturally arising CD4+ regulatory T cells for immunologic selftolerance and negative control of immune responses
Sakaguchi et al. 2004 Annu Rev Immunol 22: 531-62
Review
Regulatory T cells: mechanisms of differentiation and function
Josefowicz et al. 2012 Annu Rev Immunol 30: 531-564
Review

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