Human leukocyte antigen G (HLA-G)

Human leukocyte antigen G (HLA-G) is emerging as a significant immune checkpoint in the field of cancer research. This molecule and its receptors are potential targets for developing immune checkpoint inhibitors. Research has shown that the mRNA expression levels of Human leukocyte antigen G (HLA-G) are notably elevated in most tumor tissues and tumor cell lines. Additionally, the expression ofHuman leukocyte antigen G (HLA-G) has a positive correlation with immune checkpoint proteins PD-1 and CTLA-4.
Xu et al. 2021j Front Immunol. 12: 614773

Interestingly, the expression of Human leukocyte antigen G (HLA-G) varies with the pathological stage of the tumor in some, but not all, tumor types, ind…