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Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite that is associated with an increased risk of cardiovascular events, including stroke. TMAO contributes to the development of atherosclerosis plaque, a cause of stroke. TMAO can infiltrate the brain and worsen inflammation after stroke.
Findings indicate a potential increased risk of acute ischemic stroke (AIS) associated with elevated TMAO levels.
Ischemic stroke patients tend to have higher TMAO levels than healthy individuals, while our findings of a Mendelian randomization (MR) analysis did not support the causal role of TMAO in Ischemic stroke occurrence. Therefore, more studies are required to better understand the relationship between …