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In four geographically distinct Inflammatory Bowel Disease (IBD) cohorts (n = 537), we identify a clade of Klebsiella pneumoniae strains featuring a unique antibiotics resistance and mobilome signature strongly associated with disease exacerbation and severity.
Transfer of clinical IBD-associated Klebsiella pneumoniae strains into colitis-prone, germ-free, and colonized mice enhance intestinal inflammation.
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