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It is postulated that NRG1 fusions, through mostly transmembrane fusion partners, result in NRG1 being concentrated in proximity to HER3, leading to its constitutive activation and oncogenesis.
Nagasaka & Ou 2022 Trends in Cancer 8: 242
Recently, a monoclonal antibody that disrupts the binding of NRG1 to HER3 and HER3/HER2 heterodimerization has resulted in NRG1+ tumor shrinkage, suggesting that ‘ligand-fusion’ may be a novel mechanism of oncogenesis.
Nagasaka & Ou 2022 Trends in Cancer 8: 242
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