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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Inulin-propionate ester (IPE) & Adiposity / Obesity

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Clinical data

NCT00750438
demonstrated that over a span of 24 weeks, a daily intake of 10 grams of inulin-propionate ester was found to significantly reduce weight gain. It also altered the distribution of intra-abdominal adipose tissue, decreased intrahepatocellular lipid content, and prevented the decline in insulin sensitivity that was noted in the group receiving the inulin control. The increase in colonic propionate effectively prevents weight gain in overweight adult humans.
Chambers et al. 2015 Gut 64: 1744–1754

[NCT03322514](brain://Lctk84IQwEy_aIqkQtYD4…

References (Sources)

A pilot study to evaluate the effect of increased colonic propionate on glucose homeostasis during a hypocaloric diet
Khatib et al. 2019 Proceedings of the Nutrition Society 78 (OCE1): E10
Eﬀects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
Chambers et al. 2015 Gut 64: 1744–1754

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