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Rearranged during transfection (RET) plays a crucial role in the physiological development of certain organ systems. Activating RET alterations, through either gene fusions or point mutations, are significant oncogenic drivers in Non-Small-Cell Lung Carcinoma (NSCLC) (RET m), Thyroid cancer (RET m), and various other cancers.
Initially, RET-altered cancers were treated with multikinase inhibitors (MKIs). However, the efficacy of MKIs was modest and came with notable toxicities due to their off-target a…