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Cancer immunotherapy is now a core systemic treatment for advanced cutaneous squamous cell carcinoma (cSCC), with PD-1 checkpoint blockade as the main established immuno-oncology approach. In practice, cemiplimab and pembrolizumab are the key agents for unresectable, locally advanced, recurrent, or metastatic disease not curable with surgery or radiation, and newer perioperative uses are expanding the field.
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