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Some Escherichia coli (E. coli) strains can break down Fluorouracil (5-FU). This is the active part of tegafur. Escherichia coli (E. coli) removes it from the area lowering the drug's effectiveness. Less 5-FU means less impact on tumor cells. E. coli has certain enzymes homologous to human dihydropyrimidine dehydrogenase. They change 5-FU into harmless substances reducing its cancer-fighting power.
see also:
Drugs / Medications & Gut microbiota
[Escherichia coli (E. coli) & Fluorouracil (5-FU)](brain://ltCHgy8mT0KDHNGap4Qz6g/Escherichi…