Enterocytes / Intestinal Epithelial Cells (IECs) & Immunity

Intestinal epithelial cells respond to immune cell cytokines and their response inﬂuences and shapes the microbial community within the gut lumen
Mahapatro et al. 2021

The immune cells produce factors that Enterocytes / Intestinal Epithelial Cells (IECs) respond to, and these factors can regulate the barrier function, proliferation, and differentiation of IECs. Additionally, they can influence the composition of the microbiota.
Soderholm & Pedicor…

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the aEP7 integrin
Cepek et al. 1994 Nature 372: 190-193
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut
Mahapatro et al. 2021
Review
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
Beyaz et al. 2021 Cell Stem Cell 28: 1922-1935
Increased HLA-DR Expression by Enterocytes in Children With Celiac Disease
Arnaud-Battandier et al. 1986 Gastroenterology. 91: 1206-1212
Interactions between Intestinal Microflora/Probiotics and the Immune System
Zhang et al. 2019l
Review
Intraepithelial lymphocytes: exploring the Third Way in immunology
Hayday et al. 2001 Nat. Immunol. 2: 997-1003
Review
Maturation of the enteric mucosal innate immune system during the postnatal period.
Fulde & Hornef 2014 Immunol Rev 260: 21-34.
Review