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Severe alcoholic hepatitis (SAH), when it manifests as acute-on-chronic liver failure (ACLF), is associated with a high risk of short-term mortality. A significant factor in its development is the alteration of gut microbiota, which has been identified as a key element in the disease's pathogenesis. Modulating this gut microbiota has been proposed as a potential therapeutic approach (1).
It is an open-label non-randomized treatment trial evaluating the impact of fecal microbiota transplantation (FMT) or standard care treatment on short-term survival and improvement in scores of MELD, MELDNa, and mDF in 33 …