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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Clostridioides (Clostridium) difficile toxin A (TcdA, CdtA)

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Contents

MW: 308 kD

Clostridium (today named Clostridioides) difficile toxin A (TcdA)

The four functional domains of Clostridium (today named Clostridioides) difficile toxin A (TcdA) include the glucosyltransferase domain (GTD) (red), auto-protease domain (APD) (blue), delivery domain (yellow), and combined repetitive oligo-peptides (CROPS) domain (gray).
Mileto et al. 2019 Microbiol Spectrum 7(3): GPP3- 0015-2018

Clostridium (today named Clostridioides) difficile toxin A (TcdA) is a member of the large clostridial glucosylating toxin family, members of which are also found in several other pathogenic clostridia.
Carter et al. 2012 Trends Microbiol 20: 21-29

The C-terminal end of Clostridium (today …

References (Sources)

Baseline human gut microbiota profile in healthy people and standard reporting template
King et al. 2019
C. difficile exploits a host metabolite produced during toxin-mediated disease
Pruss & Sonnenburg 2021
Cellular uptake of Clostridium difﬁcile TcdA and truncated TcdA lacking the receptor binding domain
Gerhard et al. 2013 J Med Microbiol 62: 1414-1422
Clostridioides difﬁcile Senses and Hijacks Host Heme for Incorporation into an Oxidative Stress Defense System
Knippel et al. 2020 Cell Host & Microbe 28: 411-421
In vivo commensal control of Clostridioides difficile virulence
Girinathan et al. 2021 Cell Host & Microbe 29: 1693-1708
The role of toxin A and toxin B in the virulence of Clostridium difﬁcile
Carter et al. 2012 Trends Microbiol 20: 21-29
Third generation cephalosporins as a risk factor for Clostridium difﬁcile-associated disease: a four-year survey in a general hospital
de Lalla et al. 1989 J Antimicrob Chemother 23: 623-631

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Links

Clostridioides difficile (bacteria) - Wikipedia
https://doi.org/10.1007/978-3-319-74932-7_13
https://doi.org/10.1007/978-3-319-74932-7_13