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Indole-3-Acetic Acid (IAA, 3-IAA), originating from the bacteria Bacteroides fragilis and Bacteroides thetaiotaomicron, undergoes processing by myeloperoxidase, an enzyme derived from neutrophils. This process results in the accumulation of reactive oxygen species (ROS), which in turn increases the sensitivity of cancer cells to chemotherapy.
Lin et al. 2024 Trends in Pharmacological Sciences 45(…