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Already short time of WD feeding induced in 4-month-old animals such brain neuroinflammation events as enhanced astrogliosis, to a level comparable to that caused by the administration of pro-inflammatory LPS microglia activation in 8-month-old mice.
Also, WD feeding accelerated increased Aβ production, observed in 8-month-old animals.
the westernized nourishment pattern is an essential modifiable risk factor of AD development.
Wieckowska-Gacek et al. 2021a Front. Aging Neurosc…