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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Aryl Hydrocarbon Receptor (AhR) & Innate Lymphoid Cells (ILCs)

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Aryl Hydrocarbon Receptor (AhR) induces Notch, which is required for NKp46 + ILC, while LTi-like ILC, CP and ILF are partially dependent on Notch signaling
Lee et al. 2011a Nat. Immunol. 13: 144–151

Human NKp46 + and mouse LTi-like ILC express high levels of the transcription factor Aryl Hydrocarbon Receptor (AhR)
Cella et al. 2009 Nature 457: 722-5
Takatori et al. 2009 J Exp Med. 206: 35-41
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A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
Cella et al. 2009 Nature 457: 722-5
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
Lee et al. 2011a Nat. Immunol. 13: 144–151
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
Takatori et al. 2009 J Exp Med. 206: 35-41
Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles
Kiss et al. 2011 Science. 334: 1561–1565
The Aryl Hydrocarbon Receptor is Required for the Maintenance of Liver-Resident Natural Killer Cells.
Zhang et al. 2016 J Exp Med 213(11): 2249-57
The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells
Qiu et al. 2012 Immunity. 36: 92-104.
Tryptophan Feeding of the IDO1-AhR Axis in Host-Microbial Symbiosis
Zelante et al. 2014 Front. Immunol. 5: 640

7/1/2026