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Angiopoietin-like protein 4 (ANGPTL4) functions as an inhibitor of lipoprotein lipase and plays a role in lipid metabolism and angiogenesis. Research conducted on animals has indicated that the ANGPTL4 protein may be influenced by the gut microbiota, potentially due to elevated levels of short-chain fatty acids (SCFA), such as C4, which are present in whole-fat milk or produced through the fermentation of inulin. This study aimed to explore whether a standardized diet, either high in fat content or supplemented with inulin powder, would lead to an increase in plasma ANGPTL4 levels in overweight men, and if this increase was facilitated by changes in the composition of …