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Long-chain fatty acids (LCFAs), which are prevalent in the so-called western diet, such as dodecanoic acid, result in a decrease of short-chain fatty acids (SCFAs) in the intestine. This reduction encourages the polarization of naive T cells towards Th1 and Th17 cells in the small intestine. As a result, there is an activation of [experimental autoimmune encephalomyelitis (EAE),](brain://qv7Zmm44KkunYcZGQ5ycFA/ExperimentalAutoimmuneEnc…