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In precursor B-cell acute lymphoblastic leukemia (pB-ALL) mouse models, microbiome perturbations caused by antibiotic treatment early in life are sufficient to induce leukemia in genetically predisposed mice, even in the absence of infectious stimuli and independently of T cells.
A lack of commensal microbiota rather than the presence of specific bacteria appears to promote leukemia in genetically predisposed mice.
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