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Some Pancreatic ductal adenocarcinoma (PDAC) / Pancreatic cancer tumors contain bacteria that can potentially influence the efficacy of gemcitabine within the tumor.
While co-treatment with gemcitabine and antibiotics restored gemcitabine efficacy in murine models, it is important to note that there are many other known resistance mechanisms to gemcitabine in Pancreatic ductal adenocarcinoma (PDAC) / Pancreatic cancer (de Sousa & Monteiro 2014 Eur J Pharmacol. 741: 8-16) and consequently the clini…