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However, disease progression caused by acquired resistance to EGFR-TKIs is inevitable.
Lu et al. 2022b Expert Opinion on Emerging Drugs 27(2): 111-126
Despite their proven efficacy, resistance to these treatments inevitably develops. The most common mechanism of resistance is acquisition of another EGFR mutation, EGFR T790M (around 50–70% of cases) [6,7].
Girard 2018
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