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The expression of exhaustion markers in T cells such as TIM3, LAG3 and CTLA4 might be capable of facilitating the induction of exhaustion via non-redundant pathways even in the presence of anti-PD1 therapy (O'Donnell et al. 2017). Thommen et al. identified that co-expression of PD1, TIM3, LAG3, CTLA4 and BTLA was associated with resistance to anti-PD-1 therapy in NSCLC [63]. (aus: O'Donnell et al. 2017)…