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The safety profile of Tropifexor + Cenicriviroc combination was similar to respective monotherapies, with no new signals. Tropifexor monotherapy showed sustained Alanine aminotransferase (ALT) (EC 2.6.1.2) and body weight decreases. No substantial incremental efficacy was observed with Cenicriviroc + Tropifexor combination on Alanine aminotransferase (ALT), body weight, or in histological end points compared with monotherapy.
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