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The combination of abatacept with cyclosporine (a calcineurin inhibitor, CNI) and methotrexate (MTX) represents a significant advancement in preventing acute graft-versus-host disease (aGVHD) following hematopoietic stem cell transplantation (HSCT). This regimen, based on NCT01743131- Cyclosporine + Methotrexate vs. Methotrexate + Tacrolimus vs Abatacept + Cyclosporine + Methotrexate vs. Abatacept + Methotrexate + Tacrolimus & Acute Graft-Versus-Host Disease (acute GVHD) approved by the…