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Blocking PD-1 and PD-L1 has shown success in treating some human cancers. Clinical trials targeting these molecules have demonstrated remarkable success, generating durable clinical responses in some cancer patients. Additionally, blocking PD-1 can treat chronic viral infections. Preclinical data reveal that targeting PD-1 and its ligands can improve T cell responses and virus clearance.
see also:
Anti-PD-1 antibodies / PD-1 inhibitors & Mode of Action (MoA)
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