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AcrAB-TolC is a tripartite multidrug efflux pump in Gram‑negative bacteria, best characterized in Escherichia coli, that exports a broad range of antibiotics and toxic compounds and is a key determinant of intrinsic and acquired multidrug resistance.
AcrAB-TolC consists of:
AcrB is an inner membrane Resistance–Nodulation–Division (RND) transporter that uses proton motive force to capture drugs from the periplasm/inner membrane and move them toward the cell exterior.
AcrA is a periplasmic adaptor (me…